SAR7334 hydrochloride

产品编号 T12849LCas号 1333207-63-8

SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel.

产品编号 T12849LCas号 1333207-63-8

SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel.

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生物活性

产品描述	SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel.
靶点活性	TRPC6 current:7.9 nM
体外活性	SAR7334 inhibits TRPC6, TRPC3, and TRPC7-mediated Ca2+ influx into cells (IC50s of 9.5, 282, and 226 nM, respectively) [1][2][3], while TRPC4 and TRPC5-mediated Ca2+ entry remains unaffected. At 1 μM, SAR7334 significantly blocks Ang II-evoked calcium influx in podocytes [1]. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM, and at 100 nM, it substantially reduces TRPC6 currents [3].
体内活性	In isolated perfused lungs from mice, SAR7334 (10?mg/kg, p.o.) inhibits TRPC6-dependent acute HPV. it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].

化学信息

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (226.87 mM), Sonication is recommended.

溶液配制表

DMSO